| [Degree] | PhD | |
| [Academic Society] |
A member of The Zoological Society of Japan A member of The Molecular Biology Society of Japan A member of Japan Society of Endocrine Disrupters Research A member of Japan Society for Comparative Endocrinology |
| [Research Subjects] | Amphibian metamorphosis, Thyroid hormone, Endocrine disruption, Environmental Chemicals, Transcriptional regulation | |
| [Publications] |
[1] Murata, T. and Yamauchi K. (2005) Low-temperature arrest of the triiodothyronine-dependent transcription in Rana catesbeiana red blood cells. Endocrinology 146(1), 256-264. [2] Kudo, Y. and Yamauchi K. (2005) In vitro and in vivo analysis of the thyroid disrupting activities of phenolic and phenol compounds in Xenopus laevis. Toxicol. Sci. 84(1), 29-37. [3] Sugiyama, S., Shimada, N., Miyoshi, H. and Yamauchi, K. (2005) Detection of thyroid system-disrupting chemicals using in vitro and in vivo screening assays in Xenopus laevis. Toxcol. Sci. 88(2), 367-374. [4] Kudo, Y., Yamauchi, K., Fukazawa, H., and Terao, Y. (2006) In vitro and in vivo analysis of the thyroid system-disrupting activities of brominated phenolic and phenol compounds in Xenopus laevis. Toxicol. Sci. 92(1), 87-95. [5] Yamauchi, K., and Ishihara , A. (2006) Thyroid system-disrupting chemicals: interference with thyroid hormone binding to plasma proteins and cellular thyroid hormone signalling pathway. Rev. Environ. Health. 21(4) 229-251. |
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| [E-mail] | sbkyama |
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| [Others] |
Dr. Yamauchi's research is on the hormonal control of amphibian metamorphosis and its disruption by environmental chemicals. Current focus is on four primary topics: (1) the molecular basis of thyroid hormone action in tissue transformation during amphibian metamorphosis, (2) the role of thyroid hormone carrier proteins in plasma, (3) the molecular mechanisms of thyriod-system disrupting chemicals on amphibian metamorphosis, and (4) the development of a novel screening method of thyriod-system disrupting chemicals in the water environment. For the first topic, which transcription factors are involved in the liver transformation during metamorphosis has been investigated using the South African clawed toad Xenopus laevis and X. tropicalis. For the second topic, studies on the major component in the thyroid hormone distribution network in the extracellular compartments have found that transthyretin has a critical role in thyroid hormone delivery into target cells during amphibian metamorphosis. Researches for the third and fourth topics have been started since 2001. These researches are in progress in the combination with understanding the basic mechanism of hormonal action in the first and second topics. Biochemical, molecular and transgenesis techniques are used to assess the environmental risk of persistent organohalogenated compounds to which amphibian tadpoles are highly sensitive. Web Page of Kiyoshi Yamauchi and Akinori Ishihara |
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