| [Degree] | Doctor of Science | |
| [Academic Society] | Japanese Society of Developmental Biologists, The Zoological Society of Japan, The Japanese Society for Regenerative Medicine, The Japanese Biochemical Society |
| [Research Subjects] | Liver Development, Hepatoblasts, Hepatic Stem Cells, Regeneration, Morphogenesis, Pattern Formation, Cell-Cell Interactions, Extracellular matrix, Artificial Organ, Regenerative Medicine | |
| [Publications] |
[1] Yamasaki, H., Sada, A., Iwata, T., Niwa, T., Tomizawa, M., Xanthopoulos, K. G., Koike, T. and Shiojiri, N. (2006) Suppression of C/EBPα expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased HNF6 and HNF1β expression. Development, 133, 4233-4243. [2] Shiojiri, N. and Sugiyama, Y. (2004) Immunolocalization of extracellular matrix components and integrins during mouse liver development. Hepatology, 40, 346-355. [3] Sumazaki, R., Shiojiri, N., Isoyama S., Masu, M., Masu, K., Osawa M., Nakauchi, H. Kageyama, R. and Matsui, A. (2004) Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nature Genetics, 36, 83-87. [4] Nitou, M., Sugiyama, Y., Ishikawa, K. and Shiojiri, N. (2002) Isolation of hepatoblasts from fetal mouse liver with magnetic beads coated with anti-E-cadherin antibodies. Exp. Cell Res., 279, 330-343. [5] Niwa, T., Mochii, M., Nakamura, A. and Shiojiri, N. (2002) Plumage pigmentation and expression of its regulatory genes during quail development-Histochemical analysis using Bh mutants. Mech. Dev., 118, 139-146. |
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| [E-mail] | sbnshio |
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| [Others] | Research in our laboratory focuses on the cellular and molecular events in liver development and regeneration, and on the analysis of hepatic stem cells. We also have an active program on pattern formation in plumage coloration of quail embryos. We make extensive use of transgenic and knockout mice and mutant quails as well as tissue culture work involving hepatic stem cells purified from fetal mouse livers. | |