| [Degree] | Assistant Professor, Ph. D. | |
| [Academic Society] |
The Japanese Society of Developmental Biologists The Zoological Society of Japan The Japanese Society for the Research of Hepatic Cells |
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| [Research Subjects] |
Mechanism of early liver development. Characterization of hepatoblasts and liver progenitor cells. Comparative study of mechanisms of liver development and regeneration. |
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| [Publications] |
[1] Koike, T., and Shiojiri, N. (1996) Differentiation of the mouse hepatic primordium cultured in vitro. Differentiation , 61, 35-43. [2] Koike, T., and Yasugi, S. (1999) In vitro analysis of mesenchymal influences on the differentiation of stomach epithelial cells of the chicken embryo. Differentiation, 65, 13-25. [3] Iwashima, M., Takamatsu, M., Yamagishi, H., Hatanaka, Y., Huang, Y.Y., McGinty, C., Yamasaki, S., Koike, T. (2002) Genetic evidence for Shc requirement in TCR-induced c-Rel nuclear translocation and IL-2 expression. Proc. Natl. Acad. Sci. U.S.A., 99(7), 4544-4549. [4] Koike, T., Yamagishi, H., Hatanaka, Y., Fukushima, A., Chang, J.W., Xia, Y., Fields, M., Chandler, P., Iwashima, M. (2003) A novel ERK-dependent signaling process that regulates interleukin-2 expression in a late phase of T cell activation. J. Biol. Chem., 278(18), 15685-15692. [5] Yamasaki, H., Sada, A., Iwata, T., Niwa, T., Tomizawa, M., Xanthopoulos, K.G., Koike, T., Shiojiri, N. (2006) Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. Development, 133(21), 4233-4243. |
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| [E-mail] | stkoike |
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| [Others] | My major research interests are molecular mechanisms of liver development and regeneration. Through comparing molecular players in early liver development and in liver regeneration process, we have attempted to understand important regulatory mechanisms for histogenesis of the liver. We use mice and rats as model animals for our research, including knockout and transgenic strains. We have established a unique organ culture system of liver primordium, and we are also testing new tissue culture systems of endodermal epithelium from liver primordium, in order to analyze molecular natures which are involved in cell proliferation, differentiation and tissue interaction in early liver development. We are also trying to establish a unique experimental system, paying a special attention to liver progenitor cells and the dynamics of their nuclei, to search for molecules involved in liver regeneration using chemical- and drug-induced liver injury models. We welcome students who dare to and love to explore new scientific findings together. | |