ISHIHARA Akinori
[Degree] Assistant Professor, Ph. D. (Chiba University)
[Academic Society] The Japan Society of Endocrine Disrupters Research, The Zoological Society of Japan
[Research Subjects] Molecular biology, Bioinformatics, Biochemistry
[Publications] [1]Ishihara A, Makita Y, Yamauchi K. Gene expression profiling to examine the thyroid hormone-disrupting activity of hydroxylated polychlorinated biphenyls in metamorphosing amphibian tadpole. J Biochem Mol Toxicol. 2011 in press.
[2]Matsumoto E, Ishihara A, Tamai S, Nemoto A, Iwase K, Hiwasa T, Shibata S, Takiguchi M. Time of Day and Nutrients in Feeding Govern Daily Expression Rhythms of the Gene for Sterol Regulatory Element-binding Protein (SREBP)-1 in the Mouse Liver. J Biol Chem. 2010 285(43):33028-36.
[3]Yamauchi K, Ishihara A. Evolutionary changes to transthyretin: developmentally regulated and tissue-specific gene expression. FEBS J. 2009 276(19):5357-66.
[4]Ishihara A, Rahman FB, Leelawatwattana L, Prapunpoj P, Yamauchi K. In vitro thyroid hormone-disrupting activity in effluents and surface waters in Thailand. Environ Toxicol Chem. 2009 28(3):586-94.
[5]Eguchi R, Ishihara A, Yamauchi K. Interaction of diethylstilbestrol and ioxynil with transthyretin in chicken serum. Comp Biochem Physiol C Toxicol Pharmacol. 2008 147(3):345-50.
[6]Ishihara A, Matsumoto E, Horikawa K, Kudo T, Sakao E, Nemoto A, Iwase K, Sugiyama H, Tamura Y, Shibata S, Takiguchi M. Multifactorial regulation of daily rhythms in expression of the metabolically responsive gene spot14 in the mouse liver. J Biol Rhythms. 2007 22(4):324-34.
[7]Yamauchi K, Ishihara A. Thyroid system-disrupting chemicals: interference with thyroid hormone binding to plasma proteins and the cellular thyroid hormone signaling pathway. Rev Environ Health. 2006 21(4):229-51.
[8]Adachi-Uehara N, Kato M, Nimura Y, Seki N, Ishihara A, Matsumoto E, Iwase K, Ohtsuka S, Kodama H, Mizota A, Yamamoto S, Adachi-Usami E, Takiguchi M. Up-regulation of genes for oxidative phosphorylation and protein turnover in diabetic mouse retina. Exp Eye Res. 2006 83(4):849-57.
[9]Sakao E, Ishihara A, Horikawa K, Akiyama M, Arai M, Kato M, Seki N, Fukunaga K, Shimizu-Yabe A, Iwase K, Ohtsuka S, Sato T, Kohno Y, Shibata S, Takiguchi M. Two-peaked synchronization in day/night expression rhythms of the fibrinogen gene cluster in the mouse liver. J Biol Chem. 2003 278(33):30450-7.
[10]Ishihara A, Nishiyama N, Sugiyama S, Yamauchi K. The effect of endocrine disrupting chemicals on thyroid hormone binding to Japanese quail transthyretin and thyroid hormone receptor. Gen Comp Endocrinol. 2003 134(1):36-43.
[11]Yamauchi K, Ishihara A, Fukazawa H, Terao Y. Competitive interactions of chlorinated phenol compounds with 3,3',5-triiodothyronine binding to transthyretin: detection of possible thyroid-disrupting chemicals in environmental waste water. Toxicol Appl Pharmacol. 2003 187(2):110-7.
[12]Ishihara A, Sawatsubashi S, Yamauchi K. Endocrine disrupting chemicals: interference of thyroid hormone binding to transthyretins and to thyroid hormone receptors. Mol Cell Endocrinol. 2003 199(1-2):105-17.
[13]Yamauchi K, Eguchi R, Shimada N, Ishihara A. The effects of endocrine-disrupting chemicals on thyroid hormone binding to Xenopus laevis transthyretin and thyroid hormone receptor. Clin Chem Lab Med. 2002 40(12):1250-6.
[14]Fok AK, Yamauchi K, Ishihara A, Aihara MS, Ishida M, Allen RD. The vacuolar-atpase of Paramecium multimicronucleatum: gene structure of the B subunit and the dynamics of the V-ATPase-rich osmoregulatory membranes. J Eukaryot Microbiol. 2002 49(3):185-96.

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